Réaction #5086

Équation de réaction

4-(3-chlorophenyl)-piperazine

sodium hydride

epichlorohydrin

→

4-(3-chlorophenyl)-1-(2,3-epoxypropyl)piperazine

Conditions de réaction

Traitement

1. 1
   Extractionthe reaction mixture was extracted with 100 ml of ethyl acetate
2. 2
   Lavagethe extract was washed 5 times with 100 ml of water
3. 3
   Séchagedried with anhydrous magnesium sulfate
4. 4
   AutreThe solvent was removed by evaporation
5. 5
   Autreto obtain the residue which
6. 6
   Autrewas purified by means of a silica gel column chromatography (eluent: ethyl acetate: n-hexane=1:1)

Mode opératoire

To a mixture of 1.50 g of 4-(3-chlorophenyl)-piperazine and 0.31 g of sodium hydride was added 2.4 ml of epichlorohydrin and the reaction mixture as stirred at room temperature for 30 minutes. After the reaction was completed, the reaction mixture was extracted with 100 ml of ethyl acetate, and the extract was washed 5 times with 100 ml of water, then dried with anhydrous magnesium sulfate. The solvent was removed by evaporation to obtain the residue which was purified by means of a silica gel column chromatography (eluent: ethyl acetate: n-hexane=1:1) to obtain 1.66 g of 4-(3-chlorophenyl)-1-(2,3-epoxypropyl)piperazine as in the form of an oily substance.

Source