Réaction #5070

ord-2bbab0f4ae63457f992a8d6c141b0c62

Équation de réaction

[F-].[K+]
Potassium fluoride
COC(=O)c1cccc(I)c1
Methyl 3-iodobenzoate
C=[CH][Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC
vinyl tributyltin
→
CCc1cccc(C(=O)OC)c1
Methyl 3-ethylbenzoate

Réactifs

[F-].[K+]
Potassium fluoride
COC(=O)c1cccc(I)c1
Methyl 3-iodobenzoate
C=[CH][Sn]([CH2]CCC)([CH2]CCC)[CH2]CCC
vinyl tributyltin

Réactifs

c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
tetrakis(triphenylphosphine)palladium

Solvants

O
water
Cc1ccccc1
toluene
CCOC(C)=O
ethyl acetate

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    TempératureThe solution was heated
  2. 2
    Températureat reflux
  3. 3
    workup.STIRRINGto stir under N2 for 15 minutes
  4. 4
    Lavagewashed with water
  5. 5
    ExtractionThe organic extract
  6. 6
    Séchagewas dried (MgSO4)
  7. 7
    Autreevaporated in vacuo

Mode opératoire

Methyl 3-iodobenzoate (13 g) and vinyl tributyltin (20 g) were dissolved in toluene (100 ml) and tetrakis(triphenylphosphine)palladium (0) (500 mg) added. The solution was heated at reflux with stirring under N2 for 1 day. Potassium fluoride (3 g) in water (50 ml) was added and the reaction mixture was allowed to stir under N2 for 15 minutes. The product was taken up in ethyl acetate and washed with water and then brine (×2). The organic extract was dried (MgSO4) and evaporated in vacuo.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US05242930uspto-grants-1993_09