Réaction #50635

Équation de réaction

scopoletine

epichlorohydrin

potassium carbonate

potassium iodide

→

(±)-6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   AutreAfter vacuum evaporation
2. 2
   Extractionextraction
3. 3
   Autrewith hot ethanol re-evaporation
4. 4
   Autrefusion point 143°-145° C. (from ethanol)

Mode opératoire

25.0 g (130 mmol) of scopoletine, 15.3 ml (196 mmol) epichlorohydrin, 36.0 g (260 mmol) potassium carbonate and 2.5 g of potassium iodide are agitated in 500 ml DMF under nitrogen for 3 h at 80° C. After vacuum evaporation and repeated extraction with hot ethanol re-evaporation was performed. 21.2 g (66%); fusion point 143°-145° C. (from ethanol).

Source