Réaction #505462

Équation de réaction

1,1-dimethylethyl(3R)-3-methyl-1-piperazinecarboxylate

DIPEA

HCl

4-[(trifluoromethyl)oxy]benzenesulfonyl chloride

→

1,1-Dimethylethyl(3R)-3-methyl-4-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-1-piperazinecarboxylate

Solvants

DCM

DCM

Conditions de réaction

Traitement

1. 1
   Autrethe layers were separated
2. 2
   Lavagethe organic layer was then washed with 2M NaOH solution (75 ml)
3. 3
   Autrethe organic layers were separated
4. 4
   Séchagedried (MgSO4)
5. 5
   Concentrationconcentrated to dryness

Mode opératoire

To a solution of 1,1-dimethylethyl(3R)-3-methyl-1-piperazinecarboxylate (605 mg, 2.56 mmol) in DCM (20 ml) was added DIPEA (1.12 ml, 6.39 mmol) and then portionwise 4-[(trifluoromethyl)oxy]benzenesulfonyl chloride (0.455 ml, 2.68 mmol) at room temp and the resultant mixture stirred under Ar for 16 h. DCM (75 ml) and a 1M HCl solution (75 ml) were added, the layers were separated and the organic layer was then washed with 2M NaOH solution (75 ml), the organic layers were separated, dried (MgSO4) and concentrated to dryness. 1,1-Dimethylethyl(3R)-3-methyl-4-({4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-1-piperazinecarboxylate was isolated as a slowly crystallizing white solid.

Source