Réaction #505045

Équation de réaction

but-3-ynyl 4-methylbenzenesulfonate

N-methyl piperazine

NaHCO3

→

1-(but-3-ynyl)-4-methylpiperazine

Solvants

1,2-dichloroethane

Conditions de réaction

Traitement

1. 1
   Températurewas heated to 80 C for 4.5 h
2. 2
   Extractionthe mixture was extracted with DCM (3×40 mL)
3. 3
   Concentrationconcentrated

Mode opératoire

A mixture of but-3-ynyl 4-methylbenzenesulfonate (972 mg) and N-methyl piperazine (482 μL) was heated to 80 C for 4.5 h, diluted with 1,2-dichloroethane (5 mL) and heated to 70° C. for 18 h. Saturated aq. NaHCO3 was added (10 mL) and the mixture was extracted with DCM (3×40 mL), and concentrated to afford 0.70 g of 1-(but-3-ynyl)-4-methylpiperazine as a 3:2 mixture of tosylate salt and free base.

Source