Réaction #50494

Équation de réaction

2-nitroiminothiazolidine

potassium carbonate

2-chloro-5-pyridylmethylchloride

→

3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 5 hours
2. 2
   AutreAfter the reaction
3. 3
   Autremost of the acetonitrile was removed by distillation and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   AutreAs the solid product was separated
6. 6
   Filtrationit was collected by filtration
7. 7
   AutreThe crude material was recrystallized from ethanol

Mode opératoire

A mixture of 2.9 g of 2-nitroiminothiazolidine, 2.9 g of anhydrous potassium carbonate, 3.2 g of 2-chloro-5-pyridylmethylchloride and 50 ml of acetonitrile was refluxed for 5 hours with vigorously stirring. After the reaction, most of the acetonitrile was removed by distillation and water was added to the residue. As the solid product was separated, it was collected by filtration. The crude material was recrystallized from ethanol to give desired 3-(2-chloro-5-pyridylmethyl)-2-(nitroimino)thiazolidine.

Source