Réaction #50489

Équation de réaction

2-fluoro-5-pyridylmethyl bromide

2-(nitroimino)imidazolidine

potassium carbonate

acetonitrile

→

1-(2-fluoro-5-pyridylmethyl)-2-(nitroimino)imidazolidine

Rendement 50.2%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 2 hours
2. 2
   AutreAfter the reaction
3. 3
   FiltrationThe resulting crystals were collected by filtration
4. 4
   Lavagewashed with ether

Mode opératoire

A mixture of 2-fluoro-5-pyridylmethyl bromide (9.5 g), 2-(nitroimino)imidazolidine (6.5 g), potassium carbonate (7.6 g) and acetonitrile (100 ml) was refluxed for 2 hours with stirring. After the reaction, the reaction mixture was cooled to room temperature, and cold water (100 ml) was added. The resulting crystals were collected by filtration and washed with ether to give slightly colored 1-(2-fluoro-5-pyridylmethyl)-2-(nitroimino)imidazolidine (6.0 g) as the desired compound.

Source