Réaction #50404

Équation de réaction

ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate

→

3-(2-(4-Toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoic acid

Solvants

ethanol

—

15N sodium hydroxide

Conditions de réaction

Traitement

1. 1
   LavageThen the cooled solution is washed 3 times with 50 ml of methylene chloride
2. 2
   AutreThe precipitate formed
3. 3
   Lavageis washed
4. 4
   Autredried
5. 5
   Autrerecrystallised from n-butanol

Mode opératoire

4.2 g of ethyl 3-(2-(4-toluenesulphonylamino)indan-5-yl)-3-(3-pyridyl)-prop-2-enoate are refluxed for 30 minutes in 40 ml of ethanol and 1.5 ml of 15N sodium hydroxide solution. Then the cooled solution is washed 3 times with 50 ml of methylene chloride and then acidified. The precipitate formed is washed, dried and then recrystallised from n-butanol.

Source