Réaction #5029

Équation de réaction

hydrochloric acid

7-Cyano-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid benzyl ester

sodium hydroxide

water ethanol

→

compound

Rendement 85.0%

2,3,4,5-Tetrahydro-1H-1-benzazepine-7,9-di-carboxylic acid

Rendement 85.0%

Solvants

water

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooled
2. 2
   FiltrationThe deposited crystal was collected by filtration
3. 3
   Lavagewashed with water
4. 4
   Autredried

Mode opératoire

7-Cyano-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid benzyl ester (3.30 g) and sodium hydroxide (2 g) in a mixed solution of water-ethanol (1:1, 60 ml) was refluxed for 8 hours. After cooled, water (100 ml) was added to the reaction mixture, which was then rendered to have pH 3 with concentrated hydrochloric acid. The deposited crystal was collected by filtration, washed with water and dried to give the intended compound 1.84 g (85.0%), which was then recrystallized from ethanol to give slightly yellow crystal. M.P.: 287°-288° C.

Source