Réaction #502170

Équation de réaction

4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

N-methylpiperazine

→

title compound

4-(4-Methylpiperazin-1-yl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

Conditions de réaction

Mode opératoire

In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 380 mg (3.80 mmol) of N-methylpiperazine to give 36 mg (30% of theory) of the title compound.

Source