Réaction #502156
ord-69f77c5ef71c46a1b19983c6214847db
Équation de réaction
2-(3-fluorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
piperidine
→
title compound
2-(3-Fluorobenzyl)-6-oxo-4-(1-piperidinyl)-1,6-dihydropyrimidine-5-carbonitrile
Réactifs
Aucun
Conditions de réaction
Conditions détaillées
See reaction.notes.procedure_details.
Mode opératoire
In analogy to the preparation of Example 1, 100 mg (0.36 mmol) of 2-(3-fluorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 309 mg (3.63 mmol) of piperidine to give 40 mg (35% of theory) of the title compound.