Réaction #502152

ord-3a2cf4d56287424d84f4e91e533f4bfc

Équation de réaction

CSc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
COc1ccccc1CN
2-methoxybenzylamine
COc1ccccc1CNc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
title compound
COc1ccccc1CNc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-Chlorobenzyl)-4-[(2-methoxybenzyl)amino]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 470 mg (3.43 mmol) of 2-methoxybenzylamine to give 37 mg (28% of theory) of the title compound.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US08088769B2uspto-grants-2012_01