Réaction #502111

Équation de réaction

((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol

triethylamine

tert-butylchlorodiphenylsilane

→

title compound

Rendement 106.2%

1-(((4S)-2,2-Dimethyl(1,3-dioxolan-4-yl))methoxy)-2,2-dimethyl-1,1-diphenyl-1-silapropane

Rendement 106.2%

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Lavagethe reaction mixture was washed with water, brine
2. 2
   Séchagedried over sodium sulfate
3. 3
   Filtrationfiltered
4. 4
   Autreevaporated

Mode opératoire

To a solution of ((4R)-2,2-dimethyl-1,3-dioxolan-4-yl)methan-1-ol (9 g, 68.6 mmol) in anhydrous dichloromethane (40 mL) were added triethylamine (11.2 mL), tert-butylchlorodiphenylsilane (19.8 g, 372 mmol), and N,N-dimethylaminopyridine (DMAP, 418 mg, 3.4 mmol) at room temperature under a nitrogen atmosphere. The reaction mixture was stirred at room temperature overnight. It was then diluted with additional dichloromethane and the reaction mixture was washed with water, brine, dried over sodium sulfate, filtered and evaporated to give the title compound (27 g) which was used in the next step without further purification.

Source