Réaction #502106

Équation de réaction

1H-indazole-3-carboxylic acid

N,O-dimethylhydroxylamine hydrochloride

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

pyridine

→

compound

Rendement 69.1%

N-Methoxy-N-methyl-1H-indazole-3-carboxamide

Rendement 69.1%

Solvants

tetrahydrofuran

Conditions de réaction

Traitement

1. 1
   ConcentrationThe mixture is concentrated
2. 2
   AutreThe yellow precipitate obtained
3. 3
   Lavageis washed with water
4. 4
   Autredried under reduced pressure

Mode opératoire

In a round-bottomed flask, 4.0 g of 1H-indazole-3-carboxylic acid, 2.6 g of N,O-dimethylhydroxylamine hydrochloride, 9.4 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 8.4 ml of pyridine are placed in 120 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 20 h. The mixture is concentrated and the residue is taken up in water. The yellow precipitate obtained is washed with water and then dried under reduced pressure. 3.5 g of compound are obtained.

Source