Réaction #502098

Équation de réaction

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

Rendement 93.2%

2-(4-Chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

Rendement 93.2%

Solvants

n-propanol

Conditions de réaction

Traitement

1. 1
   workup.WAITThe reaction mixture is left
2. 2
   Températureto cool
3. 3
   Concentrationconcentrated under reduced pressure
4. 4
   Autrethe organic phase is then separated
5. 5
   Séchagedried over magnesium sulphate
6. 6
   Autrethe solvent is then evaporated off under reduced pressure

Mode opératoire

2.5 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 2.65 g of 2-bromo-1-(4-chlorophenyl)ethanone in 76 ml of n-propanol are placed in a round-bottomed flask. 1.33 g of sodium hydrogen carbonate are added thereto. The mixture is heated at 80° C. for 16 h. The reaction mixture is left to cool and concentrated under reduced pressure. The residue is taken up between water and ethyl acetate, the organic phase is then separated by settling out and dried over magnesium sulphate, and the solvent is then evaporated off under reduced pressure. 3.75 g of compound are obtained.

Source