Réaction #502097

Équation de réaction

sodium borohydride

5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde

→

compound

Rendement 37.3%

{5-[2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-yl}methanol

Rendement 37.3%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Autrethe solvent is then evaporated off under reduced pressure
2. 2
   AutreThe organic phase is separated
3. 3
   Séchagedried over sodium sulphate
4. 4
   Concentrationconcentrated under reduced pressure

Mode opératoire

122 mg of sodium borohydride are added, in small portions, to 104 mg of 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-carbaldehyde dissolved in 20 ml of methanol. The mixture is subsequently stirred at ambient temperature for 2 hours, and the solvent is then evaporated off under reduced pressure. The residue is taken up between dichloromethane and water. The organic phase is separated, dried over sodium sulphate and concentrated under reduced pressure. 39 mg of compound are obtained.

Source