Réaction #50201

Équation de réaction

3-butyn-1-ol

t-butyldimethylsilyl chloride

imidazol

→

title compound ( h )

5-(t-butyldimethylsiloxy)-3-pentyne

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONThe reaction mixture was treated in the conventional manner
2. 2
   Autrethe obtained crude product
3. 3
   workup.DISTILLATIONwas distilled

Mode opératoire

To a solution of 3-butyn-1-ol (g) (10.0 g) in DMF (80 ml) were added t-butyldimethylsilyl chloride (21.5 g) and imidazol (10.6 g), and the resultant mixture was kept at 35° C. for 7 hours. The reaction mixture was treated in the conventional manner and the obtained crude product was distilled to give the title compound (h).

Source