Réaction #5020

Équation de réaction

cis-cyclopentane-1,3-dicarboxylic acid

→

anhydride

Rendement 79.0%

3-Oxabicyclo[3.2.1]octan-2,4-dione

Rendement 79.0%

Solvants

acetic anhydride

Conditions de réaction

Traitement

1. 1
   AutreThe excess acetic anhydride and acetic acid were removed by evaporation in vacuo
2. 2
   Autreto give a solid which
3. 3
   Autrewas triturated under diethyl ether

Mode opératoire

A solution of 1.63 g of cis-cyclopentane-1,3-dicarboxylic acid in 8.2 ml of acetic anhydride was heated in an oil bath at ca. 100° C. for 45 minutes. The excess acetic anhydride and acetic acid were removed by evaporation in vacuo to give a solid which was triturated under diethyl ether. This afforded 1.14 g (79% yield) of the title anhydride.

Source