Réaction #50114
ord-8409bc67e73e4ef5a1aefeac82158792
Équation de réaction
Réactifs
Réactifs
Solvants
Conditions de réaction
Traitement
- 1Températurewere heated
- 2Températureto reflux for 3 h
- 3Températurethe mixture was again heated
- 4Températureto reflux for 3 h
- 5Extractionextracted with ether
- 6Concentrationconcentrated
- 7workup.ADDITIONa 3N sodium hydroxide solution was added to the ether phase (while the mixture
- 8Autrewas removed
- 9Lavagethe material was washed once with ether
- 10Extractionwas extracted with ether (4×15 cm3)
- 11Séchagedried over MgSO4
- 12Filtrationfiltered
- 13Autreevaporated down
- 14AutreThe crude product obtained
- 15Autrewas purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95)
Mode opératoire
0.65 g (3.69 mmol) of epoxide 2l (a mixture of 2l, 2l', 2l" above) in solution in 3 cm3 of anhydrous DMF were heated to reflux for 3 h; 91% of transposition ketone 6b was then detected by macrobore GC (verification by mass/GC coupling). 0.86 g (2 eq.) of DMAP were then added and the mixture was again heated to reflux for 3 h. It was acidified (pH=1) with 3N HCl, extracted with ether, concentrated, and a 3N sodium hydroxide solution was added to the ether phase (while the mixture was kept stirred for 5 to 10 min), the ether phase was removed and the material was washed once with ether. The aqueous phase was acidified using a solution with 3N HCl (pH=1) and was extracted with ether (4×15 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 0.10 g of phenol 4h were obtained (macrobore GC purity>97%). The yield of compound 4h was 22%.