Réaction #4995

Équation de réaction

3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

aluminum isopropoxide

→

desired product

Rendement 54.0%

3-(1-hydroxybutyl)-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole

Rendement 54.0%

Solvants

isopropanol

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was heated
2. 2
   Températureto reflux for 48 hours
3. 3
   AutreAfter evaporation of isopropanol, water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   ExtractionThe aqueous solution was extracted with ethylacetate
6. 6
   AutreAfter evaporation of ethylacetate
7. 7
   Autrethe residue was purified by column chromatography(hexane: ethylacetate=3:2)

Mode opératoire

0.316 g of 3-propylcarbonyl-5-[(2,4-dichlorophenoxy)methyl]-1,2,4-oxadiazole and 0.20 g of aluminum isopropoxide were added to 10 ml of isopropanol. The mixture was heated to reflux for 48 hours. After evaporation of isopropanol, water was added to the residue. The aqueous solution was extracted with ethylacetate. After evaporation of ethylacetate, the residue was purified by column chromatography(hexane: ethylacetate=3:2) to provide 0.17 g of the desired product(yield: 54.0%).

Source