Réaction #49908

Équation de réaction

N'-t-butyl-N,N'-dibenzoylhydrazine

Methoxymethyl chloride

→

N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   AutreThe layers were separated
2. 2
   Lavagethe toluene layer was washed several times with water (until the water washes
3. 3
   SéchageThe toluene solution was dried over anhydrous magnesium sulfate
4. 4
   Autrethe toluene removed under vacuum

Mode opératoire

N'-t-butyl-N,N'-dibenzoylhydrazine (2 g, 0.007M) was stirred at room temperature in a two phase system of toluene-50% sodium hydroxide with 100 mg of phase transfer catalyst (tetra-n-butylammonium hydrogen sulfate). Methoxymethyl chloride (1.2 g, 0.015M) was added dropwise and the mixture was stirred 3 hours. The layers were separated and the toluene layer was washed several times with water (until the water washes were neutral). The toluene solution was dried over anhydrous magnesium sulfate and the toluene removed under vacuum to afford N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine as a thick oil.

Source