Réaction #49504

Équation de réaction

ammonium fluoride

hydroxymethyltributyltin

4-Trifluoromethanesulfonyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

hydroxymethyltributyltin

→

4-hydroxymethyl-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

Rendement 23.4%

Solvants

1,4-dioxane

1,4-dioxane

Conditions de réaction

Traitement

1. 1
   Autresynthesized in a similar manner to the method
2. 2
   workup.STIRRINGstirred for 2.3 hours
3. 3
   workup.STIRRINGby stirring for 4 hours
4. 4
   Extractionextracted with ethyl acetate
5. 5
   LavageThe organic layer was washed with saturated brine
6. 6
   Séchagedried over sodium sulfate
7. 7
   AutreThe solvent was evaporated under reduced pressure
8. 8
   AutreThe residue was purified by preparative thin-layer chromatography (chloroform/methanol=10/1)

Mode opératoire

4-Trifluoromethanesulfonyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (80.0 mg, 0.135 mmol) was dissolved in 1,4-dioxane (2.4 mL), and the solution was added with hydroxymethyltributyltin (87 mg, 0.27 mmol) synthesized in a similar manner to the method described in Synthetic Communications, 1994, vol. 24, p. 1117, and tetrakis(triphenylphosphine)palladium (12.5 mg, 0.0108 mmol), followed by stirring at 90° C. for 2.7 hours under argon atmosphere. The mixture was further added with tetrakis(triphenylphosphine)palladium (6.3 mg, 0.054 mmol) and stirred for 2.3 hours. Further, the mixture was added with hydroxymethyltributyltin (44 mg, 0.14 mmol), tetrakis(triphenylphosphine)palladium (6.3 mg, 0.0054 mmol) and 1,4-dioxane (1.2 mL), followed by stirring for 4 hours. The reaction mixture was added with 10% aqueous ammonium fluoride solution and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by preparative thin-layer chromatography (chloroform/methanol=10/1) to obtain 4-hydroxymethyl-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (15.0 mg, yield 23%).

Source