Réaction #4950

Équation de réaction

Dimethylamine

epichlorohydrin

methylamine

→

1-dimethylamino-3-methylamino-2-propanol hydrochloride

Rendement 84.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGStirring
2. 2
   Autrefor one hour
3. 3
   Autreroom temperature overnight
4. 4
   AutreThe solvents were evaporated

Mode opératoire

Dimethylamine 22.6 g, 40% solution (0.2 mole) was added dropwise to a solution of 16 ml of epichlorohydrin (0.2 mole) in 100 ml of methanol at 5° C. stirring in an ice bath. After two hours at 5° C. a chilled solution of 86 ml methylamine of 40% solution (1 mole) was poured into the reaction mixture. Stirring was continued in ice bath for one hour and then room temperature overnight. The solvents were evaporated and the clear oil was pumped under vacuum at 75° C. for 1.5 hr to give 28.23 g (~84% yield) of 1-dimethylamino-3-methylamino-2-propanol hydrochloride (I) as the main product.

Source