Réaction #49392

Équation de réaction

3-amino-6-bromophthalimide

2-benzofuraneboronic acid

tri(o-tolyl)phosphine

triethylamine

→

Compound 171

Rendement 33.0%

3-Amino-6-(benzofuran-2-yl)phtalimide

Rendement 33.0%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Autrefollowed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=15/1)

Mode opératoire

In a similar manner to Step 2 of Example 1, 3-amino-6-bromophthalimide (80.0 mg, 0.332 mmol) was dissolved in acetonitrile (4.0 mL), and, the solution was treated with 2-benzofuraneboronic acid (161 mg, 0.996 mmol), palladium acetate (9.0 mg, 0.040 mmol), tri(o-tolyl)phosphine (24.3 mg, 0.080 mmol) and triethylamine (0.463 mL, 3.32 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=15/1) to obtain Compound 171 (30.1 mg, yield 33%).

Source