Réaction #4930

Équation de réaction

dimethylamine

2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one

dimethylamine

→

2-[2-(Dimethylamino)ethyl]-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one dihydrochloride

Conditions de réaction

Traitement

1. 1
   Autreto evaporate
2. 2
   Autrethe residue was partitioned between chloroform and dilute sodium hydroxide
3. 3
   ConcentrationThe chloroform layer was concentrated
4. 4
   workup.DISSOLUTIONthe residue, the free base of the title compound, was dissolved in isopropyl alcohol
5. 5
   Autrereacted with hydrogen chloride

Mode opératoire

A solution of 1.5 g (0.0058 mole) of 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one in 20 ml of dimethylamine was stirred at 25° C. in a sealed container for 72 hr. The excess dimethylamine was allowed to evaporate and the residue was partitioned between chloroform and dilute sodium hydroxide. The chloroform layer was concentrated and the residue, the free base of the title compound, was dissolved in isopropyl alcohol and reacted with hydrogen chloride. The resulting hydrochloride salt weighted 1.5 g (77%), m.p.>250° C.

Source