Réaction #490256

Équation de réaction

sodium carbonate

N-methoxymethyl-N-methylpyrrolidinium chloride

N-methyl-N-methoxymethylpyrrolidinium chloride

→

desired product

N-methoxymethyl-N-methylpyrrolidinium carbonate

Solvants

water

Conditions de réaction

Traitement

1. 1
   AutreThe mixture was reacted at room temperature for 0.5 hour
2. 2
   Autrewhereby the reaction was terminated
3. 3
   ConcentrationThe reaction mixture was concentrated
4. 4
   Séchagedried in vacuum, and 100 ml of ethyl alcohol
5. 5
   workup.ADDITIONwas added to the residue
6. 6
   Autreto remove insoluble sodium chloride
7. 7
   workup.DISSOLUTIONThe resulting product was dissolved in dichloromethane
8. 8
   Filtrationthe solution was filtered with a membrane
9. 9
   Filtrationfilter again
10. 10
    Concentrationthe filtrate was concentrated in a vacuum
11. 11
    Autredried

Mode opératoire

A 1.60 g quantity of sodium carbonate (product of Wako Pure Chemical Ind. Ltd.) was dissolved in 18 g of deionized water, and 5.01 g of N-methoxymethyl-N-methylpyrrolidinium chloride was added to the solution. The mixture was reacted at room temperature for 0.5 hour, whereby the reaction was terminated. The reaction mixture was concentrated and dried in vacuum, and 100 ml of ethyl alcohol was added to the residue to remove insoluble sodium chloride. The resulting product was dissolved in dichloromethane, the solution was filtered with a membrane filter again, and the filtrate was concentrated in a vacuum and dried, giving 5.41 g of the desired product.

Source