Réaction #487510

Équation de réaction

dichlorodiphenyl methane

N,N-dimethylformamide

benzophenone

thionyl chloride

→

dichlorodiphenyl methane toluene

Solvants

toluene

water

Conditions de réaction

Traitement

1. 1
   Autrea reaction at a reaction temperature of 75° C. for 12 hours
2. 2
   workup.ADDITIONwere added
3. 3
   Températureunder ice-cooling
4. 4
   Autreliquid separation
5. 5
   Autreremove the aqueous layer

Mode opératoire

25.6 mL of N,N-dimethylformamide (DMF) (manufactured by Wako Pure Chemical Industries Ltd.) was added to 60.1 g of benzophenone (manufactured by Wako Pure Chemical Industries Ltd., and then 60.2 mL of thionyl chloride (manufactured by Wako Pure Chemical Industries Ltd.) was added dropwise thereto, followed by performing a reaction at a reaction temperature of 75° C. for 12 hours. After confirming the production of the dichlorodiphenyl methane by means of 1H-NMR, 60 mL of toluene and 80 mL of water were added thereto under ice-cooling to perform liquid separation and remove the aqueous layer, thereby obtaining a dichlorodiphenyl methane/toluene solution.

Source