Réaction #4872

Équation de réaction

ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate

sodium hydroxide

→

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

Rendement 75.1%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Températurethe mixture is refluxed for 30 minutes
2. 2
   Températureunder heating
3. 3
   TempératureAfter cooling
4. 4
   Autrecrystalline precipitates
5. 5
   Filtrationare collected by filtration
6. 6
   Lavagewashed with methanol
7. 7
   AutreCrystalline precipitates
8. 8
   Filtrationare collected by filtration
9. 9
   Autredried

Mode opératoire

16.0 g of ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are added to a mixture of 160 ml of methanol and 30 ml of an aqueous 2N sodium hydroxide solution, and the mixture is refluxed for 30 minutes under heating. After cooling, crystalline precipitates are collected by filtration and washed with methanol. The crystals are suspended in 30 ml of water. Then, the suspension is adjusted to pH 3 with 2N hydrochloric acid. Crystalline precipitates are collected by filtration and dried. 11.4 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained.

Source