Réaction #48715

Équation de réaction

water

ammonium acetate

3-fluoro-5-propoxy-benzaldehyde

nitromethane

→

desired compound

Rendement 69.8%

1-Fluoro-3-((E)-2-nitro-vinyl)-5-propoxy-benzene

Rendement 69.8%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   TempératureCool to room temperature
2. 2
   ExtractionExtract with ethyl acetate
3. 3
   Séchagedry over magnesium sulfate
4. 4
   Filtrationfilter
5. 5
   Concentrationconcentrate

Mode opératoire

Add ammonium acetate (2.63 g, 34.08 mmol) to 3-fluoro-5-propoxy-benzaldehyde (2.25 g, 12.35 mmol) and nitromethane (3.09 g, 50.63 mmol) in acetic acid (41 mL) at room temperature and heat in 140° C. oil bath for 3 hours. Cool to room temperature and pour into water. Extract with ethyl acetate, dry over magnesium sulfate, filter and concentrate to afford 1.94 g (69.8%) of the desired compound as an oil.

Source