Réaction #48501

Équation de réaction

WSC

(2S)-3-[(6-Chloronaphthalen-2-yl)sulfony]-2-hydroxypropionic acid

1-(piperidin-4-yl)tetrahydropyrimidin-2(1H)-one

HOBt

→

title compound

1-(1-{(2S)-3-[(6-Chloronaphthalen-2-yl)sulfonyl]-2-hydroxypropanoyl}piperidin-4-yl)tetrahydropyrimidin-2(1H)-one

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   ConcentrationThe reaction mixture was concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with an aqueous sodium bicarbonate solution
3. 3
   Extractionextracted with dichloromethane
4. 4
   LavageThe extract was washed with an aqueous 5% citric acid solution and saturated saline solution
5. 5
   Séchagedried over sodium sulfate
6. 6
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
7. 7
   AutreThe residue was purified by silica gel column chromatography (ethyl acetate to ethyl acetate/methanol=10/1)

Mode opératoire

(2S)-3-[(6-Chloronaphthalen-2-yl)sulfony]-2-hydroxypropionic acid, 1-(piperidin-4-yl)tetrahydropyrimidin-2(1H)-one, and HOBt (23.0 g) were dissolved in DMF, WSC was added thereto, and the mixture was stirred at room temperature for 15 hours. The reaction mixture was concentrated under reduced pressure, diluted with an aqueous sodium bicarbonate solution, and extracted with dichloromethane. The extract was washed with an aqueous 5% citric acid solution and saturated saline solution, and dried over sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate to ethyl acetate/methanol=10/1) to obtain the title compound as a colorless powder.

Source