Réaction #483611

ord-a014953f350845a1874951c88993d885

Équation de réaction

O=C(O)Cc1c(C(=O)c2ccc(Cl)cc2)[nH]c2ccc(F)cc12
5-fluoro-2-[(N-methoxy-N-methylamino)carbonyl]indole
O=C(O)Cc1c(C(=O)c2ccc(Cl)cc2)[nH]c2ccc(F)cc12
[2-(4-Chlorobenzoyl)-5-fluoro-1H-indol-3-yl]acetic Acid
Clc1cccc(Br)c1
3-bromochlorobenzene
→
O=C(O)Cc1c(C(=O)c2cccc(Cl)c2)[nH]c2ccc(F)cc12
title compound
O=C(O)Cc1c(C(=O)c2cccc(Cl)c2)[nH]c2ccc(F)cc12
[2-(3-Chlorobenzoyl)-5-fluoro-1H-indol-3-yl]acetic Acid

Réactifs

O=C(O)Cc1c(C(=O)c2ccc(Cl)cc2)[nH]c2ccc(F)cc12
5-fluoro-2-[(N-methoxy-N-methylamino)carbonyl]indole
O=C(O)Cc1c(C(=O)c2ccc(Cl)cc2)[nH]c2ccc(F)cc12
[2-(4-Chlorobenzoyl)-5-fluoro-1H-indol-3-yl]acetic Acid
Clc1cccc(Br)c1
3-bromochlorobenzene

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

The title compound was prepared according to the procedure described in step 2 of Example 7 from 5-fluoro-2-[(N-methoxy-N-methylamino)carbonyl]indole (Example 21, step 1) and 3-bromochlorobenzene.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06608070B1uspto-grants-2003_08