Réaction #4816

Équation de réaction

chloromethyl n-dodecanoate

quinuclidine

KBr

→

n-Dodecanoyloxymethylquinuclidinium Chloride

Solvants

ether

Conditions de réaction

Traitement

1. 1
   Autreto react together at room temperature for 48 hrs
2. 2
   Autrethe mixture was triturated in anydrous ether overnite
3. 3
   AutreThe solid was isolated by filtration under a nitrogen atmosphere
4. 4
   Lavagethoroughly washed with anhydrous ether
5. 5
   SéchageAfter drying in vacuo over calcium sulfate at room temperature
6. 6
   Autre2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

Mode opératoire

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

Source