Réaction #48024

Équation de réaction

m-trifluoromethyl-benzamidoxime

potassium hydroxide

epichlorohydrine

→

m-trifluoromethyl-N-(2,3-epoxypropoxy)-benzamidine

Solvants

water

dimethyl sulphoxide

water

Conditions de réaction

Traitement

1. 1
   Autrekept in a refrigerator overnight
2. 2
   Extractionthe mixture was extracted with ethyl acetate (4×250 ml)
3. 3
   LavageThe combined organic phases were washed with water
4. 4
   Autredried
5. 5
   workup.ADDITIONtreated with charcoal
6. 6
   Autreevaporated to dryness

Mode opératoire

50 g (0.245 mol) of m-trifluoromethyl-benzamidoxime and 33.7 g (0.6 mol) of potassium hydroxide was dissolved in a mixture of dimethyl sulphoxide and 170 ml of water, and the mixture was cooled to 0° C. 48 ml (0.6 mol) of epichlorohydrine was added, and the reaction mixture was stirred at 0° C. for 5 hours, then kept in a refrigerator overnight. Next day 250 ml of water was added, and the mixture was extracted with ethyl acetate (4×250 ml). The combined organic phases were washed with water, dried, treated with charcoal and evaporated to dryness, to yield m-trifluoromethyl-N-(2,3-epoxypropoxy)-benzamidine, as a colorless oil.

Source