Réaction #4791

Équation de réaction

racemic (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate

→

(R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate

Solvants

isopropanol

Conditions de réaction

Mode opératoire

Sufficient racemic (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate is dissolved in isopropanol to form a 52.6% by weight (R,S)-1-(4-methoxybenzyl)-octahydroisoquinolinium acetate solution. The solution is seeded at 20° C. with about 1%, relative to the weight of the solution, of (S)-acetate and is stirred at 0° C. for 2 to 3 hours. The crystallized (S)-acetate is filtered off with suction and washed with tert.-butyl methyl ether.

Source