Réaction #47891

Équation de réaction

1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione

compound F1

1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione

thiosemicarbazide

→

5-(4-Iodo-phenyl)-6H-pyrazolo[1,5-c]pyrimidine-7-thione

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Températureis heated
2. 2
   Températureto reflux temperature
3. 3
   Filtrationis filtered
4. 4
   Lavagewashed with methanol
5. 5
   AutreThe filtrate with the product is purified by flash silica gel chromatography

Mode opératoire

A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.

Source