Réaction #47844

Équation de réaction

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

cyclohexylamine

→

titled compound

Rendement 24.0%

1-cyclohexylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Rendement 24.0%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   Autrethe solvent was removed under a reduced pressure
2. 2
   AutreThe resulting residue was purified by flash chromatography

Mode opératoire

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and cyclohexylamine (132.86 mg, 0.15 mL, 1.34 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 25 mg of the titled compound (yield: 24%).

Source