Réaction #47842

Équation de réaction

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

morpholine

→

titled compound

Rendement 83.0%

6-methoxy-1-morpholine-4-yl-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Rendement 83.0%

Solvants

THF

Conditions de réaction

Traitement

1. 1
   Autrethe solvent was removed under a reduced pressure
2. 2
   AutreThe resulting residue was purified by flash chromatography

Mode opératoire

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (10 mg, 0.40 mmol) obtained in Example 18 was dissolved in THF (15 mL), and morpholine (175.01 mg, 0.18 mL, 2.01 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 126 mg of the titled compound (yield: 83%).

Source