Réaction #47839

Équation de réaction

1-Amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic acid ethyl ester

1-amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

acetyl chloride

triethylamine

→

titled compound

Rendement 47.0%

1-acetylamino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic Acid Ethyl Ester

Rendement 47.0%

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Autreat 0° C
2. 2
   Lavagewashed with saturated saline
3. 3
   Extractionextracted with dichloromethane
4. 4
   AutreThe organic layer was separated
5. 5
   Séchagedried over anhydrous MgSO4
6. 6
   Concentrationconcentrated under a reduced pressure
7. 7
   AutreThe resulting residue was purified by flash chromatography

Mode opératoire

1-Amino-3-phenyl-6-(3-phenyl-propoxy)-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.07 mmol) prepared in Example 21 was dissolved in dichloromethane (10 mL), and acetyl chloride (30.15 mg, 0.37 mmol) and triethylamine (40 mg, 0.37 mmol) were added thereto in order at 0° C. The mixture was stirred for 24 hrs at RT, washed with saturated saline and extracted with dichloromethane. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 15 mg of the titled compound (yield: 45%).

Source