Réaction #47826

Équation de réaction

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

Rendement 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Rendement 52.0%

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   AutreThe organic layer was separated
3. 3
   Concentrationconcentrated under a reduced pressure
4. 4
   AutreThe resulting residue was purified by flash chromatography

Mode opératoire

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

Source