Réaction #4779

Équation de réaction

5-bromomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine

N-methylpiperazine

→

6-methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine

Solvants

isopropyl alcohol

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 6 hours
2. 2
   AutreAfter evaporating the solvent
3. 3
   workup.DISSOLUTIONthe residue was dissolved in chloroform
4. 4
   Lavagewashed with saturated aqueous sodium chloride
5. 5
   Séchagedried over magnesium sulfate
6. 6
   AutreThe filtrate was evaporated under reduced pressure
7. 7
   Lavageeluting with chloroform
8. 8
   workup.ADDITIONThe fractions containing the object compound
9. 9
   Concentrationconcentrated under reduced pressure
10. 10
    AutreThe residue was recrystallized from diethyl ether

Mode opératoire

A mixture of 5-bromomethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine (1.5 g), N-methylpiperazine (1.17 g) in isopropyl alcohol (15 ml) was refluxed for 6 hours. After evaporating the solvent, the residue was dissolved in chloroform, washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The filtrate was evaporated under reduced pressure, and the residue was subjected to column chromatography on alumina (100 g) eluting with chloroform. The fractions containing the object compound were combined and concentrated under reduced pressure. The residue was recrystallized from diethyl ether to give 6-methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine. (0.30 g).

Source