Réaction #4765

Équation de réaction

2-[(E)-4-chloro-2-butenyloxy]-5-nitrobenzaldehyde

methyl acetoacetate

methyl 3-aminocrotonate

→

dimethyl 4-[2-[(E)-4-chloro-2-butenyloxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Rendement 48.8%

Solvants

iso-propanol

Conditions de réaction

Traitement

1. 1
   Autrethe solution obtained
2. 2
   Températurewas refluxed for 3.5 hours
3. 3
   Températureunder heating
4. 4
   TempératureAfter cooling
5. 5
   Filtrationthe precipitated crystals were collected by filtration

Mode opératoire

5.2 g of 2-[(E)-4-chloro-2-butenyloxy]-5-nitrobenzaldehyde, 2.4 g of methyl acetoacetate and 2.3 g of methyl 3-aminocrotonate was dissolved in 30 ml of iso-propanol, and the solution obtained was refluxed for 3.5 hours under heating. After cooling, the precipitated crystals were collected by filtration to give 4.4 g of dimethyl 4-[2-[(E)-4-chloro-2-butenyloxy]-5-nitrophenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. (mp. 206°-207° C.). The product obtained was used directly for the next process without purification.

Source