Réaction #4754

Équation de réaction

2-(4-bromobutoxy)-5-methylsulfonylbenzaldehyde

methyl acetoacetate

3-aminocrotonic acid methyl ester

→

dimethyl 4-[2(4-bromobutoxy)-5-methylsulfonylphenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Rendement 53.0%

Solvants

isopropanol

Conditions de réaction

Traitement

1. 1
   Températurethe solution was heated for 5 hours
2. 2
   TempératureAfter cooling
3. 3
   Autreprecipitated crystals
4. 4
   Filtrationwere collected by filtration
5. 5
   Autrerecrystallized from methanol

Mode opératoire

7.6 g of 2-(4-bromobutoxy)-5-methylsulfonylbenzaldehyde, 2.6 g of methyl acetoacetate and 2.9 g of 3-aminocrotonic acid methyl ester were dissolved in 16 ml of isopropanol, and the solution was heated for 5 hours. After cooling, precipitated crystals were collected by filtration, and recrystallized from methanol to give 6.3 g of dimethyl 4-[2(4-bromobutoxy)-5-methylsulfonylphenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Source