Réaction #4744

Équation de réaction

ammonia

3-hydroxybenzaldehyde

3-methylpiperidine

formic acid

→

3-[(3-Methylpiperidin-1-yl)methyl]phenol

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températurewith cooling
2. 2
   TempératureWhen the reaction mixture has cooled to room temperature
3. 3
   Filtrationthe precipitated solid is filtered off
4. 4
   Autrerecrystallised from ethanol

Mode opératoire

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

Source