Réaction #4724

Équation de réaction

Hydrogen peroxide

N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   Températurethe reaction mixture is briefly heated to boiling
2. 2
   FiltrationThe sulphur which separates is filtered off hot with the aid of active charcoal
3. 3
   Concentrationthe filtrate is concentrated by evaporation
4. 4
   Autrepurified by preparative layer chromatography

Mode opératoire

2 ml of 30% Hydrogen peroxide are added to 1.58 g (4 mmol) of N-methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarbothioamide in 30 ml of ethanol and the reaction mixture is briefly heated to boiling. The sulphur which separates is filtered off hot with the aid of active charcoal and the filtrate is concentrated by evaporation and purified by preparative layer chromatography.

Source