Réaction #4705

Équation de réaction

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methylisocyanate

Ether

→

N-Methyl-2-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]aminothioxomethyl]-hydrazine carboxamide

Solvants

THF

Conditions de réaction

Traitement

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Autrethe precipitation
3. 3
   Filtrationfiltered
4. 4
   Lavagewashed with ether
5. 5
   Autrerecrystallised from ethanol

Mode opératoire

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.40 g (6 mmol) of methylisocyanate are added and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete the precipitation, and the precipitate is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

Source