Réaction #470396

Équation de réaction

N-(2-nitrophenyl)biphenyl-2-amine

hydrogen

→

N1-(biphenyl-2-yl)benzene-1,2-diamine

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe solution was filtered through Celite
2. 2
   Autreto remove the catalyst, Celite
3. 3
   Lavagewas washed with dichloromethane
4. 4
   Autrethe filtrate was evaporated
5. 5
   Autreto yield a brown oil, 14.8 g (84%)
6. 6
   AutreThe product was used for the next step without further purification

Mode opératoire

N-(2-nitrophenyl)biphenyl-2-amine (19.69 g, 67.8 mmol), 10% palladium on carbon (0.29 g, 0.27 mmol), and 150 mL of ethanol was added to a Parr hydrogenator bottle. The mixture was hydrogenated on a Parr hydrogenator until no more hydrogen was taken up by the solution. The solution was filtered through Celite to remove the catalyst, Celite was washed with dichloromethane, the filtrate was evaporated to yield a brown oil, 14.8 g (84%). The product was used for the next step without further purification.

Source