Réaction #470392

Équation de réaction

2,6-diisopropylaniline

2-fluoronitrobenzene

potassium fluoride

→

desired product

Rendement 47.9%

2,6-diisopropyl-N-(2-nitrophenyl)aniline

Rendement 47.9%

Solvants

water

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooled to room temperature
2. 2
   ExtractionThe mixture was then extracted with dichloromethane (200 mL) for three times
3. 3
   AutreThe solvent was evaporated
4. 4
   Autrethe residue was purified by column chromatography

Mode opératoire

2,6-diisopropylaniline (25 g, 141 mmol), 2-fluoronitrobenzene (10 g, 70 mmol), and potassium fluoride (6.2 g, 106 mmol) were mixed in a one-neck flask. The mixture was heated up to 180° C. under nitrogen for 48 hours. After cooled to room temperature, water (200 mL) was added. The mixture was then extracted with dichloromethane (200 mL) for three times. The solvent was evaporated and the residue was purified by column chromatography using 20% of dichloromethane in hexanes. 10 g of desired product was obtained.

Source