Réaction #470387

Équation de réaction

N1-phenylbenzene-1,2-diamine

benzaldehyde

→

desired product

Rendement 37.0%

1,2-diphenyl-1H-benzo[d]imidazole

Rendement 37.0%

Solvants

methoxylethanol

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was heated up
2. 2
   Températureto reflux for 48 hours
3. 3
   Autrethe solvent was evaporated
4. 4
   AutreThe residue was purified by column chromatography

Mode opératoire

N1-phenylbenzene-1,2-diamine (4.15 g, 22 mmol) and benzaldehyde (2.1 g, 20 mmol) were mixed with methoxylethanol (60 ml) in a three-neck flask. The mixture was heated up to reflux for 48 hours. After cooled to room temperature, the solvent was evaporated. The residue was purified by column chromatography using dichloromethane to 5% of ethyl acetate in dichloromethane as eluent. 2 g of desired product was obtained.

Source