Réaction #470378

Équation de réaction

Methylchloroformate

maleimide

NMM

→

product

Rendement 55.0%

N-(Methoxycarbonyl)maleimide

Rendement 55.0%

Solvants

EtOAc

Conditions de réaction

Traitement

1. 1
   Filtrationfiltered
2. 2
   Lavagewashed with EtOAc
3. 3
   Lavagewashed with cold water
4. 4
   Séchagedried over anhydrous Na2SO4
5. 5
   FiltrationAfter filtration and evaporation under vacuum a pink solid
6. 6
   Autrewas obtained
7. 7
   AutrePurification by column chromatography on silica gel (Hexane-EtOAc, 1:1

Mode opératoire

Methylchloroformate (4.4 mL, 56.7 mmol, 1 eq) was added to a solution of maleimide (5.5 g, 56.7 mmol, 1 eq) and NMM (6.2 mL, 56.7 mmol, 1 eq) in 200 mL of EtOAc at 0° C. The suspension was stirred at 0° C. for 30 minutes, filtered and washed with EtOAc. Filtrate and washings were combined and washed with cold water and dried over anhydrous Na2SO4. After filtration and evaporation under vacuum a pink solid was obtained. Purification by column chromatography on silica gel (Hexane-EtOAc, 1:1, v/v) provided the product (4.8 g, 55%).

Source