Réaction #470359

Équation de réaction

N-methylpyrrolidine

Chloromethyl methyl ether

→

desired product

N-Methyl-N-Methoxymethylpyrrolidinium Chloride

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   Températuregradually heated to a higher temperature
2. 2
   workup.STIRRINGstirred at room temperature for 10 hours
3. 3
   Autrethe reaction
4. 4
   FiltrationThe reaction mixture was filtered
5. 5
   Lavagethe resulting solid product was washed with 150 g of toluene and 150 g of acetone
6. 6
   AutreThe washed product was dried in a vacuum

Mode opératoire

A 30.0 g quantity of N-methylpyrrolidine (reagent, product of Tokyo Kasei Co., Ltd.) was dissolved in 120 g of toluene, followed by replacement with nitrogen. Chloromethyl methyl ether (31.2 g, reagent, product of Tokyo Kasei Co., Ltd.) was added dropwise to the solution at 5° C. over a period of 1 hour. The mixture was stirred at 5° C. for 1 hour, then gradually heated to a higher temperature, and stirred at room temperature for 10 hours to complete the reaction. The reaction mixture was filtered, and the resulting solid product was washed with 150 g of toluene and 150 g of acetone. The washed product was dried in a vacuum to obtain 53.7 g of the desired product (white solid).

Source